TITLE
COMFREY (SYMPHYTUM OFFICINALE L.): PHYTOCHEMICAL PROFILE, ANTIOXIDANT PROPERTIES, AND THERAPEUTIC POTENTIAL
AUTHOR(S)
Kristiyan Stefanov1*, Dragomir Vassilev2
ABSTRACT
Comfrey (Symphytum officinale L.) is a perennial medicinal plant with a long history of use in traditional medicine for wound healing, pain relief, and inflammation reduction. Modern clinical research, including randomized controlled trials, has confirmed the efficacy and safety of topical comfrey preparations in alleviating pain, swelling, and inflammation in muscles and joints. These effects are particularly relevant in managing degenerative arthritis, acute back pain, and sports-related injuries such as sprains and strains, establishing comfrey as a reliable agent in evidence-based phytotherapy. Recent studies have expanded the understanding of comfrey beyond its traditional uses, recognizing it as a rich source of biologically active compounds with potential applications in the food and pharmaceutical industries. Its roots and leaves contain alkaloids, phenolic acids, flavonoids, tannins, and polysaccharides, which collectively contribute to strong antioxidant, anti-inflammatory, and tissueregenerative effects. Notably, the presence of inulin and fructooligosaccharides (FOS) indicates possible prebiotic properties, supporting gut microbiota balance and metabolic health. This study aims to investigate the phytochemical profile, antioxidant capacity, and biological activity of S. officinale. The findings highlight comfrey’s potential as a functional and medicinal plant resource, suitable for developing nutraceuticals, dietary supplements, and topical products, while supporting sustainable and eco-friendly bioproduct innovation within the modern bioeconomy.
DOI
How to cite this article:
Kristiyan Stefanov1*, Dragomir Vassilev2, COMFREY (SYMPHYTUM OFFICINALE L.): PHYTOCHEMICAL PROFILE, ANTIOXIDANT PROPERTIES, AND THERAPEUTIC POTENTIAL, UNITECH – SELECTED PAPERS - 2025